The United Nations political affairs chief is due to arrive in Pyongyang on Tuesday for a rare visit.
The trip by Jeffrey Feltman is the first by a senior UN official in six years.
North Korea had extended an invitation to the UN in September to visit for a “policy dialogue”.
It comes after last week’s launch of what North Korea called its “most powerful” intercontinental ballistic missile, claiming it could hit the US.
Mr Feltman, a former US diplomat and the highest ranking American in the UN, will be in Pyongyang until Friday.
A UN spokesman told reporters that Mr Feltman will be meeting senior officials including foreign minister Ri Yong-ho. He is not scheduled to meet North Korean leader Kim Jong-un.
The invitation, first informally issued in September, was confirmed on 30 November – the day after North Korea launched its most recent missile.
The last visit by a senior UN official was when the former UN aid chief Valerie Amos travelled there in October 2011. Mr Feltman’s predecessor Lynn Pascoe also visited in 2010.
The trip by Mr Feltman comes during a period of high tensions following North Korea’s test launch of a missile which drew another round of international condemnation.
The US ambassador to the UN Nikki Haley had said last week that if war broke out, the North Korean regime would be “utterly destroyed”.